Addressing the lot of responses...
Eating poison ivy or fire: Co-evolution with a species is critically dependent on the manner of interaction between the species. That is, using a plant as a poison for millennia does not mean it's also safe to eat. It does mean it's likely to be a good poison.
Modern crops are different from older species, just by hybridization/breeding: Yes. But they're based on the genes of crops that have co-evolved with humans, using a process that's also naturally occurring (though using it somewhat artificially). And they may indeed be lacking benefits afforded by progenitor cultivars and species. Likely no one tested the resulting breeds for the subtle (and certainly not the unknown) benefits of the original species when selecting their "successes". Older species are probably better for you, generally, if not as tasty or pretty.
Many or most modern food plants are a novelty to any given person's ancestry: True, but not a novelty to humans in general. So the question here is how much pressure is put on the humans to evolve versus the crops? Also, there are differences between what foods different races can tolerate.
What's precaution [wikimedia.org] and what's science-stifling irrational fear:
Yes, absence of evidence is not the same thing as evidence of absence....but in the absence of hard evidence, how are the opponents of GMO any different that the opponents of vaccination?
As stupid as that may sound at first, there is actually a very important concept being asked about. What's prudent and what's ignorantly fearful?
We need to weigh several factors. The possibility and degree of benefit. The possibility and degree of harm. The amount of knowledge we have about the topic. The amount of knowledge we have about the scope of the topic. (Rumsfeld's "known knowns" and "unknown unknowns" idea.) My review of these leaves me on the side of playing it safe.
The primary wildcard that makes me sit up and pay close attention to folks playing with the genes of food crops is the fact that "Life finds a way." Crops breed out of our control. We've seen it already with GMO. If you're not using a time-tested method for changing crop genes (breeding, for example), you want to figure out more clearly what kind of results you'll be making. Fuck it up in a bad way and the "life finds a way" factor could leverage your mistake into a catastrophe.
But, even if life does tend to find a way, I'd be for scientists experimenting with Frankenstein GMO crops in tightly controlled environments, and testing the results over the course of a couple generations of test subjects. But I guess that's infeasible.
Likely we'll all be test subjects. And then we'll just have to wait a few generations to iron out the big problems, and a few hundred generations to smooth out the relationship, and a few hundred more generations to polish it out to a beautifully symbiotic sheen.
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